Heidelberg Pharma AG. (7/13/22). "Press Release: Heidelberg Pharma and Chiome Bioscience Sign Exclusive, Target-Specific Research and Option Agreement for the Development of an Antibody Drug Conjugate (ad hoc)". Ladenburg.

	Organisation	Heidelberg Pharma Research GmbH
	Group	Heidelberg Pharma (Group)
	Organisation 2	Chiome Bioscience Inc. (TSE Mothers: 4583)
	Group	Chiome Bioscience (Group)
	Product	ATAC® technology
	Product 2	antibody-drug conjugate (ADC)
	Person	Wimmer, Sylvia (Heidelberg Pharma 202203 Corporate Communciations formerly Wilex 201403 Corporate Communications)
	Person 2	Arnold, Katja (MC Services 201309 CIRO Executive Director before Wilex AG + CAT Consultants)

Ad hoc announcement
Inside information pursuant to Article 17 MAR

Heidelberg Pharma AG (FSE: HPHA) and Chiome Bioscience Inc., Tokyo, Japan, (Tokyo: 4583) today announced the signing of an exclusive, target-specific research and option agreement. Heidelberg Pharma Research GmbH signed this collaboration, which will combine one of Chiome’s monoclonal antibodies against one specific target with Heidelberg Pharma’s proprietary ATAC ® platform.

Under the terms of the agreement, Chiome will have access to Heidelberg Pharma’s Amanitin toxin-linker platform technology and has an option for an exclusive, target-specific license for global development and commercialization rights to the product candidate resulting from the research collaboration.

Heidelberg Pharma would be eligible to receive an option fee, development- and sales-related milestone payments of up to 105 million Euro as well as tiered royalties in the mid-upper single digit range.

+++ End of the ad hoc announcement +++

About Heidelberg Pharma

Heidelberg Pharma is an oncology specialist and the first company to develop the toxin Amanitin into cancer therapies using its proprietary ATAC ® technology and to advance the biological mode of action of the toxin as a novel therapeutic principle. The proprietary technology platform is being applied to develop the Company’s own therapeutic ATACs ® as well as in third-party collaborations. The lead candidate HDP-101 is a BCMA ATAC in clinical development for multiple myeloma. HDP-102, a CD37 ATAC for Non-Hodgkin lymphoma and HDP-103, a PSMA ATAC for metastatic castration-resistant prostate cancer, are in preclinical testing.

Heidelberg Pharma AG is based in Ladenburg, Germany, and is listed on the Frankfurt Stock Exchange: ISIN DE000A11QVV0 / WKN A11QVV / Symbol HPHA. More information is available at http://www.heidelberg-pharma.com/.

ATAC® is a registered EU trademark of Heidelberg Pharma Research GmbH.

About Chiome Bioscience

Chiome Bioscience is a clinical stage biotechnology company. Chiome’s focus is on discovery and development of antibody-based therapeutics in the disease areas with unmet medical needs. Chiome has a proprietary antibody generating technology named ADLib® System and several antibody discovery and preclinical programs. Chiome was founded in 2005, is listed in Tokyo stock exchange Growth (code: 4583), and located in Tokyo, Japan.

For more information, please visit www.chiome.co.jp.

Contact

Heidelberg Pharma AG

Sylvia Wimmer
Tel.: +49 89 41 31 38-29
Email: investors@hdpharma.com
Gregor-Mendel-Str. 22, 68526 Ladenburg

IR/PR support

MC Services AG
Katja Arnold (CIRO)
Managing Director & Partner
Tel.: +49 89 210 228-40
Email: katja.arnold@mc-services.eu

This communication contains certain forward-looking statements relating to the Company's business, which can be identified by the use of forward-looking terminology such as "estimates", "believes", "expects", "may", "will" "should" "future", "potential" or similar expressions or by a general discussion of the Company's strategy, plans or intentions. Such forward-looking statements involve known and unknown risks, uncertainties and other factors, which may cause our actual results of operations, financial condition, performance, or achievements, or industry results, to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Given these uncertainties, prospective investors and partners are cautioned not to place undue reliance on such forward-looking statements. We disclaim any obligation to update any such forward-looking statements to reflect future events or developments.

Record changed: 2023-06-05