Dren Bio Inc.

https://www.drenbio.com

LinkedIn: https://www.linkedin.com/company/dren-bio

Dren Bio is a privately held, clinical-stage biopharmaceutical company pioneering the discovery and development of novel first-in-class antibody therapeutics for the treatment of cancer, autoimmune, and other serious diseases. The Company’s lead product candidate, DR-01, is a first-in-class antibody therapeutic capable of selectively depleting terminally differentiated cytotoxic cells such as autoreactive CD8 T cells, which are known to play a pathogenic role in various cancer and autoimmune diseases. DR-01 is currently being evaluated in a Phase 2 study in patients with cytotoxic lymphomas and is expanding into various autoimmune indications. In addition to DR-01, Dren Bio’s Targeted Myeloid Engager and Phagocytosis Platform is a bispecific antibody-based technology that induces potent depletion of pathogenic cells, protein aggregates, and other disease-causing agents by engaging a novel phagocytic receptor that is selectively expressed on myeloid cells. Bispecific antibodies generated from the platform are specifically engineered to enable controlled myeloid cell activation only in the presence of the target antigen, which may result in greater therapeutic indexes and offer superior safety profiles compared to other therapeutic modalities such as T-cell engagers and Antibody Drug Conjugates (ADCs). The Company’s lead platform program, DR-0201, is capable of engaging both tissue-resident and trafficking myeloid cells to induce deep B cell depletion via targeted phagocytosis. DR-0201 has demonstrated a favorable preclinical safety profile in multiple non-human primate studies with no cytokine release syndrome or neurotoxicity observed and is currently being evaluated in a Phase 1 study in B-NHL patients. Collectively, Dren Bio’s two distinct clinical programs represent a unique opportunity to potentially achieve an immune reset in multiple autoimmune diseases, by inducing deep depletion of pathogenic B cells using DR-0201 and by selectively depleting autoreactive T cells using DR-01. The Company’s preclinical pipeline includes multiple bispecific antibodies generated from its platform focused on oncology, immunology, and neurology. *

	Start	2019-01-01 established
	Industry	DR-01 (Dren Bio)
	Industry 2	Targeted Myeloid Engager and Phagocytosis Platform (bispecific antibody-based technology)
	Person	Tomasevic, Nenad (Dren Bio 202407 CEO + Founder)
	Person 2	Mehta, Amit (Dren Bio 202310– COO + CBO before 18 years at Genentech)

	Street	384 Foster City Blvd.
	City	94404 Foster City, CA
	Tel	+1-415-737-5277
		Address record changed: 2024-07-25

Basic data	Employees	n. a.

		* Document for »About Section«: Dren Bio, Inc.. (7/24/24). "Press Release: Dren Bio Announces Strategic Collaboration with Novartis to Develop Novel Targeted Myeloid Engagers for Cancer". Foster City, CA.

		Record changed: 2024-07-27

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