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Organisation › Details

Adrenomed AG

Adrenomed AG is a privately financed biopharmaceutical company, based in Hennigsdorf near Berlin, Germany, with a clear mission to improve survival by improving vascular integrity in critically ill patients. Its lead candidate, Adrecizumab, a monoclonal antibody therapy targeting the vasoactive Adrenomedullin system, is in clinical testing for septic shock. Impaired vascular integrity is a pathology that serves a variety of medical conditions. A further indication besides sepsis is acute decompensated heart failure. About Adrenomedullin and Adrecizumab Adrenomedullin is a strong vasodilatory hormone released by endothelial cells. It is a key regulator of blood pressure and vascular tone and plays a pivotal role in the development of septic shock. Adrecizumab is a proprietary humanized monoclonal Adrenomedullin-specific antibody, as first-in-class therapy for the treatment and prevention of impaired vascular integrity, which is a hallmark of septic shock. Adrecizumab showed excellent safety & tolerability as well as high efficacy in a variety of preclinical animal models, mimicking human standard of care treatment on ICU. In several resuscitated vascular integrity models (mouse, rat, pig), Adrecizumab reduced vascular leakage, stabilized the circulation, by restoring blood pressure, normalized fluid balance and reduced vasopressor demand, improved renal function and reduced mortality from septic shock by 50%. The excellent tolerability and safety of Adrecizumab was confirmed in clinical Phase-I studies in healthy subjects with and without LPS challenge. *

 

Period Start 2010-10-20 established
Product Industry adrecizumab
Persons Person Möller, Gerald (HBM Bio Ventures 201007 Advisor former Roche + Boehringer Mannheim CEO 1995–1997)
  Person 2 Bergmann, Andreas (Sphingotec GmbH 201301 Managing Director)
     
Region Region Hennigsdorf
  Country Germany
  Street 15a Neuendorfstr.
  City 16761 Hennigsdorf
  Tel +49-3302-207780
    Address record changed: 2018-12-22
     
Basic data Employees n. a.
     
    * Document for �About Section�: Adrenomed AG. (12/11/17). "Press Release: Adrenomed AG Doses First Patient in Proof of Concept Study with Adrecizumab to Treat Patients with Early Septic Shock". Hennigsdorf.
     
   
Record changed: 2019-02-16

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