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Bicoll GmbH. (3/4/21). "Press Release: Taste Active Small Molecules in Plants Identified by Data Mining of Historical Manuscripts from China". Planegg-Martinsried.

Organisations Organisation Bicoll GmbH
  Group Bicoll (Group)
  Organisation 2 Charité Berlin, Institute for Chinese Life Sciences (ICL)
  Group Charité – Universitätsmedizin Berlin (Charité University Hospital)
Products Product sweetener
  Product 2 business development (state/region)
Index terms Index term SimLeap project–Germany (govt): grant, 202003–202101 extension of project partially funded by BMBF
  Index term 2 SimLeap project–Germany (govt): grant, 201711–2019 BMB funding €1.1m out of total project volume of €1.6m

Data mining of 40.000 historical recipes documented by healthcare practitioners in Chinese (Institute of Chinese Life Sciences, Charité Universitätsmedizin Berlin) was the basis for identifying, testing (Symrise), and confirming taste active substances (Bicoll). The use case for these compounds is two-fold: it allows to improve the taste and hence adaption of healthy low carb foods and increase compliance of patients through better tasting medicine.

Bicoll, an expert in providing novel and relevant bioactive compounds for accelerated product development, disclosed the results of the “SimLeap” research consortium’s efforts today.

These promising preliminary data were presented at the 32nd “Irseer Naturstofftage” (Poster: # P26) conference. Results show that small molecules in plant materials for which longstanding use by humans has been confirmed by freely accessible historical Chinese manuscripts contain sweet or bitter-masking activity. Sensory-guided fractionation followed by high-resolution mass spectrometry confirms the presence of sweet and bitter-masking secondary metabolites as active compounds of respective plant source materials. The relevance of the chemical findings of this study breaks new ground in terms of both, the rather well-known plant material ingredients used as drugs today, and the numerous less standardized substances of medicines used in East Asia, historically. In addition, significant improvements to the source database used for data mining were made. All these achievements combined contributed to a successful run of the SimLeap project that formally ended on 31.01.2021.

About Bicoll

The Bicoll Group is a privately-owned biopharmaceutical company which includes Bicoll GmbH headquartered near Munich in Planegg / Martinsried, Germany, and its wholly-owned subsidiary Bicoll Biotechnology (Shanghai) Co. Ltd., P.R. China.

Bicoll offers pre-clinical support with an efficient, multi-disciplinary approach to drug discovery. Dedicated to the discovery and optimization of the highest quality lead compounds, Bicoll provides services to international clients in the pharmaceutical, agrochemical, and related industries. The unique combination of expertise in high-tech natural product chemistry, as well as in medicinal chemistry, enables Bicoll to increase the quality and quantity of the drug discovery pipeline of its partner’s candidate portfolios.

For more information, please visit

About Institute of Chinese Life Sciences, Charité Universitätsmedizin Berlin

The Institute for Chinese Life Sciences (ICL) at the Charité – Universitätsmedizin Berlin was founded as an interdisciplinary institution for research and teaching with the aim of providing a serious scientific platform for the increasing interdependence of the Western and East Asian life sciences. The ICL combines basic competencies in medicine, health care, public health, life sciences, culture, history, philosophy, and ethics in China and the western world. One focus is the translational competencies of system comparisons (cultures in the past and present, governance) and cooperation.

For more information, please visit

Contact Bicoll

Maria Lamottke
+49 89 820 106 30

Contact Institute of Chinese Life Sciences

Prof. Dr. Paul U. Unschuld
Institute Director
+49 30 450 570 872

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Record changed: 2024-01-06


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