Advertisement

Picture [LSE] Life-Sciences-Europe.com – The Business Web Portal 650x65px
Document › Details

Almac Group Ltd.. (6/15/15). "Press Release: Almac Discovery Announce Ubiquitin Specific Protease Collaboration with Genentech". Craigavon.

Organisations Organisation Almac Discovery Ltd.
  Group Almac (Group)
  Organisation 2 Genentech Inc.
  Group Roche (Group)
Products Product small-molecule cancer drug
  Product 2 drug discovery
Index term Index term Roche–Almac: cancer drugs, 201506– collab $14.5m upfront + $349m milestones + royalties r+d small molecule inhibitors of USP target Genentech
Persons Person Barr, Stephen (Almac 201301 President + Managing Director of Almac Sciences)
  Person 2 Sabry, James H. (Roche 201808– Global Head Partnering joined Genentech 2010 before Arete Therapeutics + Cytokinetics)
     


Almac Discovery, a biopharmaceutical company focused on identifying and developing innovative therapeutics for the treatment of cancer, today announced a Research and Licensing agreement with Genentech, a member of the Roche Group (SIX:RO, ROG; OTCQX: RHHBY) to discover and develop small molecule inhibitors of a ubiquitin specific protease (USP) target.

Under the terms of the agreement, Almac Discovery will receive an upfront payment of $14.5 million. Almac Discovery will be eligible to receive up to $349 million in payments based on achievement of certain predetermined milestones as well as escalating tiered royalties on potential commercial sales of multiple products to the target by Genentech.

Almac Discovery’s novel, potent and selective small molecule inhibitors will be the starting point for a two-year joint research programme funded by Genentech. Genentech will be responsible for all pre-clinical and clinical development and commercialisation of products arising from the collaboration.

Tim Harrison, Vice President Drug Discovery, Almac Discovery commented “Inhibitors of ubiquitin specific proteases have been a highly sought after, yet elusive drug class, proving difficult to identify despite significant efforts from both pharmaceutical and biotech companies. Ubiquitin specific proteases have been shown to play an important role in a number of key oncogenic pathways, and the identification of potent, selective inhibitors provides an exciting opportunity to fully exploit this novel biology, as well as further demonstrating the chemical tractability of this important target class.”

Stephen Barr, President Almac Discovery, added “We’re delighted to enter into this partnership with Genentech, a like-minded research driven organisation. Genentech is an undoubted leader in oncology development and this, coupled with their in depth knowledge in the USP area, is the perfect complement for us. We feel confident that Genentech is the best partner to expedite the translation of our medicinal chemistry and biology efforts into the clinic.”

“We’re pleased to initiate this collaboration with Almac Discovery where we hope to discover and develop therapies targeting an important USP that can potentially advance the standard of care patients with cancer” said James Sabry, Senior Vice President and Global Head of Genentech Partnering.


About Almac Discovery

Almac Discovery is a research driven oncology company that is dedicated to the discovery and development of novel and innovative approaches to the treatment of cancer. Almac Discovery focuses on the discovery to preclinical stage seeking to partner programmes at an early time point with the pharmaceutical industry. Exceptionally the company will undertake clinical development to an early stage before partnering. Almac Discovery is an independent member of the Almac Group.

   
Record changed: 2017-04-02

Advertisement

Picture [LSUS] Life-Sciences-USA.com – The Business Web Portal 650x65px

More documents for Almac (Group)


To subscribe to our free, monthly newsletter for the European life sciences, please send an e-mail to info@iito.de and simply fill the subject line with the word »LSE Newsletter«

To get even more information, please take a look at our [gs] professional services offering and read the gene-sensor Product Flyer [PDF file]

Please visit also our web portals for the European life sciences and the worldwide mass spectrometry industry at Life-Sciences-Europe.com (European life sciences) and Mass-Spec-Capital.com (worldwide mass spectrometry)

Please visit also our web portals for the life sciences in German-speaking Europe (DE, AT & CH) and the worldwide mass spectrometry industry at Life-Sciences-Germany.com (life sciences in German-speaking Europe) and Mass-Spec-Capital.com (worldwide mass spectrometry)

Advertisement

Picture Kentro Design Corporate and Web Design Berlin 650x65px




» top