Product › Details
|Next higher product group||CNS drug|
|Status||2011-02-14 development existent|
Biocrea GmbH. (2/14/11). "Press Release: Biocrea Announces Novel Treatment Opportunities for CNS Diseases. Company Has Filed US Patent on Novel, Brain-penetrating PDE2 and PD10 Inhibitors". Radebeul.
biocrea, a biopharmaceutical company focusing on novel treatments for disorders of the central nervous system (CNS), today announced it has filed a patent application covering its brain-penetrating inhibitors of phosphodiesterases. These compounds constitute a new generation of promising drug candidates to address several CNS disorders that are currently lacking effective treatment options.
"Phosphodiesterases, or PDEs, are key regulators of brain signaling. Recently, PDEs have also been associated with a number of CNS diseases, and inhibiting certain PDEs in the brain bears great therapeutic potential for indications such as schizophrenia, depression, anxiety or movement disorders," said Dr. Martin Gunthorpe, CSO of biocrea. "However, a lot of opportunities are still unexplored so far. Most attempts have failed to develop small molecule PDE inhibitors that easily penetrate the brain and act with sufficient specificity and efficacy. biocrea has pioneered the development of PDE2 and PDE10 inhibitors that overcome these limitations. Therefore, our compounds open an exciting avenue for novel treatment options for severe diseases of the central nervous system."
This week, biocrea has submitted a patent application to the U.S. Patent Office (USPTO) covering compounds and uses of its proprietary PDE2 and PDE10 inhibitors.
While the inhibitors of PDE10 show excellent potential for the treatment of schizophrenia, Huntington's disease and Tourette's syndrome, the PDE2 inhibitors cover a whole spectrum of new biological activities and treatment opportunities. "As an example," Gunthorpe said, "we have demonstrated in animal models that these compounds are able to significantly improve cognitive deficits and have therapeutic potential to treat depression and anxiety."
Moreover, biocrea's brain-penetrating PDE2 inhibitors show promise for the treatment of drug-induced movement disorders. "This constitutes a completely novel therapeutic approach for this indication, a common side effect of anti-psychotic medications," Gunthorpe added.
biocrea's patent application also comprises dual inhibitors of PDE2 and PDE10 as the combination of both modes of action in one molecule results in synergistic biological effects.
The most advanced compound of biocrea's novel family of PDE inhibitors, a brain-penetrating, selective PDE2 inhibitor, has been selected to enter pre-clinical development.
biocrea focuses on the discovery and development of novel drugs for the treatment of debilitating CNS diseases such as schizophrenia, depression, and anxiety. biocrea's key expertise lies in the discovery and optimization of selective ion channel and enzyme modulators, such as phosphodiesterases (PDEs).
The company has been established by seasoned experts with an exceptional track record in the biopharmaceutical industry (e.g. Asta Medica, Degussa, GlaxoSmithKline, Biotie Therapies). Among others, the team was involved in the discovery and development of the potassium channel opener retigabine and the development of a PDE10 inhibitor portfolio for the treatment of schizophrenia in collaboration with GlaxoSmithKline and Wyeth Pharmaceuticals, now Pfizer.
Following its incorporation in November 2010, biocrea is currently implementing a comprehensive partnering and licensing strategy.
Phosphodiesterases (PDEs) are key regulators of signal transduction. As such, they are fundamental in the performance and maintenance of our daily life and health. Phosphodiesterase inhibition can thus be exploited to treat a wide variety of diseases, e.g. chronic obstructive pulmonary disease (through inhibition of PDE4) or erectile dysfunction (through inhibition of PDE5). Recent studies have revealed a striking distribution pattern of PDEs in the brain, which implies a high therapeutic potential of certain PDEs (e.g. PDE2, PDE10) to treat diseases like schizophrenia, cognition impairment, Parkinson's disease and more. Brain penetrating PDE inhibitors therefore offer a novel approach for the treatment of these debilitating diseases.
So far, validating the benefit of brain PDE inhibitors in CNS diseases has been difficult because access to brain PDEs is limited by the so-called "blood brain barrier" (BBB). The team of biocrea has overcome these limitations and developed brain-penetrating, highly specific PDE inhibitors that constitute a new generation of promising drug candidates for the treatment of CNS disorders.
Dr. Tom Kronbach
Tel.: +49 351 / 4043 3332
Fax: +49 351 / 4043 3216
Contact // Kontakt akampion Newswire:
Dr. Ludger Wess
Managing Partner, akampion
T: +49 (0)40 88 16 59 64
F: +49 (0)40 88 16 59 65
ludger (at) akampion.com
Managing Partner, akampion
T: +49 (0)30 23632768
F: +49 (0)30 23632769
ines (at) akampion.com
Record changed: 2012-02-29
More documents for CNS drug
-  AC Immune S.A.. (9/13/16). "Press Release: AC Immune Commences Proposed Initial Public Offering of Common Shares". Lausanne....
-  Boehringer Ingelheim. (8/29/16). "Press Release: Saniona and Boehringer Ingelheim Sign Collaboration Agreement in Schizophrenia". Ingelheim....
-  Denali Therapeutics Inc.. (8/25/16). "Press Release: Denali Therapeutics Announces First Clinical Trial Application, Key Collaborations and $130m Series B". South San Francisco, CA....
-  Anand, Geeta & Jeolvingaug, Frederik. (8/11/16). "News: Driven to Suicide by an ‘Inhuman and Unnatural’ Pressure to Sell. Leaving His Wife and Two Young Children Home [...] a 27-Year-old Salesman for Abbott Laboratories’ Operations in India [...] Jumped...
-  Actelion Ltd.. (7/7/16). "Press Release: Actelion to Enter Phase II Clinical Development with New Dual Orexin Receptor Antagonist in Patients with Insomnia". Allschwil....
-  Boehringer Ingelheim. (5/23/16). "Press Release: Boehringer Ingelheim and BioMed X Start New Project". Ingelheim....
-  Lead Discovery Center GmbH. (5/11/16). "Press Release: LDC and Boehringer Ingelheim Join Forces to Discover a Novel Approach for the Treatment of Schizophrenia". Dortmund....
-  R-Biopharm AG. (4/19/16). "Press Release: R-Biopharm AG to Collaborate with HMNC Brain Health on Complementary Diagnostic Test for Optimization of Depression Treatment". Darmstadt....
-  Newron Pharmaceuticals S.p.A.. (3/29/16). "Press Release: Newron Receives Complete Response Letter from US FDA for Xadago (safinamide)". Milan....
-  Newron Pharmaceuticals S.p.A.. (3/1/16). "Press Release: Newron Pharmaceuticals Reports 2015 Financial Results". Milan....
To subscribe to our free, monthly newsletter for the life sciences in German-speaking Europe (DE, AT & CH), please send an e-mail to email@example.com and simply fill the subject line with the word »LSG newsletter«
To get even more information, please take a look at our [gs] professional services offering and read the gene-sensor Product Flyer [PDF file]
Please visit also our web portals for the European life sciences and the worldwide mass spectrometry industry at Life-Sciences-Europe.com (European life sciences) and Mass-Spec-Capital.com (worldwide mass spectrometry)
Please visit also our web portals for the life sciences in German-speaking Europe (DE, AT & CH) and the worldwide mass spectrometry industry at Life-Sciences-Germany.com (life sciences in German-speaking Europe) and Mass-Spec-Capital.com (worldwide mass spectrometry)