Picture BIO Deutschland Dt Biotechnologietage DBT 2017 Hannover April 600x60px
Document › Details

Geneva Bioinformatics (GeneBio) S.A.. (8/2/10). "Press Release: HUG Choose SmileMS for Emergency Clinical Toxicology Screening". Geneva.

Region Region Genève (Geneva) GE
  Country Switzerland
Organisations Organisation Geneva Bioinformatics S.A. (GeneBio)
  Group GeneBio (Group)
  Organisation 2 Hôpitaux Universitaires de Genève (HUG)
  Group University of Geneva (Université de Genève, UNIGE)
Product Product SmileMS software
Index terms Index term GeneBio–Univ Geneva: SmileMS software, –201007 collab development by GeneBio + HUG + SIB
  Index term 2 Univ Geneva–Bruker Corp: mass spectrometer, 201008 supply existent amaZon X for evaluation at HUG Dept of Genetic and Laboratory Medicine
Persons Person Hochstrasser, Denis (University Geneva 201005 Professor HUG Head Dept Genetic and Laboratory Medicine)
  Person 2 Nahas, Nasri G. (Spinomix 201506 CEO before GeneBio CEO)

After close collaboration and thorough testing for over a year, SmileMS small molecule identification software is now relied upon for emergency clinical toxicology screening at Geneva University Hospitals (HUG - Hopitaux Universitaires de Geneve).

Medical doctors treating patients with toxicological symptoms need fast and reliable identification of the causing toxic agent. Existing screening methods in clinical routine laboratories often rely on spectral comparisons of LC-UV-DAD data in addition to classical immuno-assays and chemical methods. Liquid Chromatography Tandem Mass Spectrometry (LC-MS-MS) combined with spectral library searching has now proven itself to be a quick and powerful diagnostic technique.

Professor Denis Hochstrasser, Head of the Department of Genetic and Laboratory Medicine at HUG, commented, "there was a strong need for a more robust approach to small molecule identification at toxic and therapeutic levels and with the algorithm developed by GeneBio we have now successfully implemented an efficient solution for routine analysis using LC-MS-MS. Thanks to SmileMS, medical doctors can provide patients with diagnosis or therapy quickly and with high confidence."

About toxicological screening at HUG

The team developed a multi-target drugs screening method in biological matrices based on LC-MSMS using the AB SCIEX QTRAP 3200 and Bruker amaZon X instruments. Drug identification is carried out by a library search approach using SmileMS developed by GeneBio. It is based on searching product ion scan spectra against the Weinmann library and a home-made Bruker HCT/amaZon library.

Dr. Marc Fathi of the Toxicology Laboratory at HUG explained, "the great advantage over vendor-specific solutions is that you can use one piece of software for data interpretation which can handle experimental spectra from different instruments and libraries from different sources including our own library, as well as generate a report in a single format."

The immediate benefits of the application of SmileMS in the identification of drugs and toxins in acute clinical toxicology are:
* Powerful automated identification with less false positives
* Screening positive and negative ions in a single run
* Intuitive interface appropriate to routine analysis
* One software for searching multiple spectral libraries and for use with the main MS instruments
* Unambiguous compound identification within 20 minutes at therapeutic levels

The SmileMS solution

SmileMS version 1.0 was made available to the public by GeneBio on July 20, 2010. Developed in collaboration with SIB Swiss Institute of Bioinformatics and Professor Denis Hochstrasser's team, SmileMS targets a growing need for efficient and automatable processes using LC-MS techniques for routine daily compound analysis.

Nasri Nahas, the CEO of GeneBio announced, "We developed this tool by capitalizing on our company's experience in the field of bioinformatics and in close partnership with the team at HUG. It is with great pride that we can confirm that SmileMS is relied upon in a hospital and emergency room context."

The future looks bright for GeneBio whose reputation continues to grow. "We are very excited about the potential for SmileMS and look forward to announcing further successful projects to highlight the versatility of this new platform," added Nasri Nahas.

Catherine Noyes
Marketing Manager, GeneBio
Tel. +41.22.702.99.00

Record changed: 2014-04-23


Picture VIB Conferences Revolutionizing Next Gen Sequencing 2017 600x60px

More documents for GeneBio (Group)

To subscribe to our free, monthly newsletter for the life sciences in German-speaking Europe (DE, AT & CH), please send an e-mail to and simply fill the subject line with the word »LSG newsletter«

To get even more information, please take a look at our [gs] professional services offering and read the gene-sensor Product Flyer [PDF file]

Please visit also our web portals for the European life sciences and the worldwide mass spectrometry industry at (European life sciences) and (worldwide mass spectrometry)

Please visit also our web portals for the life sciences in German-speaking Europe (DE, AT & CH) and the worldwide mass spectrometry industry at (life sciences in German-speaking Europe) and (worldwide mass spectrometry)


Picture Sacura e.tract software 2017 600x60px wpa

» top


Picture [iito] Twitter iitoLifeScience Life Sciences Mass Spec 120x120px Picture AB Sciex Berliner LCMSMS Symposium 2017 Right 120x80px Picture VIB Conferences Revolutionizing Next Gen Sequencing 2017 120x180px Picture BIO Deutschland Dt Biotechnologietage DBT 2017 Hannover April 120x240px Picture EBD Group BIO-Europe Spring 2017 BES Barcelona Spain March 120x180px Picture Sacura e.tract software 2017 120x240px wpetmf Picture [LSE] – The Business Web Portal 120x600px Banner Fairtec GmbH Solutions for Smarter Business Events Exhibitions 120x120px Picture [iito] Twitter iitoLifeScience Life Sciences Mass Spec 120x120px