Haplogen Bioscience GmbH. (9/10/18). "Press Release: Cyclenium Pharma and Haplogen Bioscience Announce Granting of EUREKA Label and Funding to Develop Novel Therapies in Severe Viral Diseases". Montréal, QC & Vienna.

	Organisation	Haplogen Bioscience GmbH
	Organisation 2	Cyclenium Pharma Inc.
	Product	drug discovery
	Product 2	virostatic agent
	Index term	Cyclenium–Haplogen: virostatic agents, 201505– collab drug discovery small molecule macroycle inhibitors using CMRT technology
	Person	Thomas, Helmut (Cyclenium Pharma 201809 CEO + CSO)
	Person 2	Casari, Georg (CeMM 201211 Director + Haplogen 201211 CEO + founder before Oridis Biomed + Cellzome + Lion Bioscience)

Cyclenium Pharma Inc., an emerging pharmaceutical company specializing in the discovery and development of novel pharmaceutical agents based on their proprietary small molecule macrocyclic chemistry, and Haplogen Bioscience GmbH, a biotechnology company developing cutting-edge antiviral therapeutics, announced today the awarding of the internationally-recognized EUREKA label in recognition of the high degree of innovation and market potential for their joint program on the development of pan-flaviviral pharmaceuticals. EUREKA, established in 1985, is an intergovernmental network of funding bodies and ministries of more than 40 countries, primarily in Europe, and associated countries, including Canada. The prestigious EUREKA label is given to companies developing high value-added projects passing stringent assessment criteria.

This project, the result of a close and highly effective collaboration between the two companies that started in early 2015, focuses on the development of novel small molecule macrocycle inhibitors of an enzyme target critical to the life cycle of flaviviruses. It exploits Cyclenium’s proprietary CMRT™ (“smart”) drug discovery technology together with Haplogen’s exquisite expertise in flaviviral biology to identify new agents for therapeutic and prophylactic use against all major pathogenic organisms from this family, including dengue, Zika, West Nile, Japanese encephalitis and yellow fever viruses. Cyclenium will be responsible for all medicinal chemistry efforts associated with current lead optimization to clinical candidates, while Haplogen Bioscience will continue to thoroughly characterize the biological and pharmacological properties of these novel molecules. The partners intend to jointly develop and commercialize the resulting drug candidates.

For these late stage discovery efforts, Cyclenium has received a significant contribution from the National Research Council of Canada Industrial Research Assistance Program (NRC IRAP), a federally-funded program that supports small and medium-sized business and the commercialization of innovative Canadian technologies, while Haplogen Bioscience has been awarded a grant from the Austrian Research Promotion Agency (FFG), the country’s national funding agency for industrial research and development.

“We greatly appreciate the EUREKA organization, NRC IRAP and the FFG for recognizing the importance, excellent potential and global value of this collaborative project, which reflects the highly fruitful and synergistic nature of our relationship with Haplogen Bioscience,” stated Helmut Thomas, Ph.D., President, Chief Executive Officer & Chief Scientific Officer of Cyclenium Pharma. “The promising results we have obtained to date open an exciting path towards the discovery and development of potent pan-flaviviral inhibitors, which would have significant worldwide impact in fighting and preventing these infections.”

“We are excited about the potential opening up when expertise combines across continents and we experience the EUREKA support as a booster to leverage this potential for us. With this partnership we establish a strong foothold in Canada, a country with flourishing biotechnology, and the Vienna BioCenter in Austria, a life science and biotechnology hub that plays in the world’s top league of life science research.” remarked Dr. Georg Casari, CEO of Haplogen Bioscience “With our program, we want to make an impact and develop a medical treatment for patients that are currently left with no options.”

Flaviviral infections cause a variety of clinical manifestations ranging from relatively mild rash and flu-like symptoms, to extremely serious diseases, such as encephalitis and hemorrhagic fever. Globally, tens of thousands of deaths and millions of illnesses are the result of these infections with escalating incidence being observed both within and outside the usual tropical and subtropical regions. The recent Zika outbreak in South America and the serious long-term difficulties in containing dengue disease underscore the increasingly urgent need for new therapies to battle these viral pathogens.

About Cyclenium Pharma Inc.

Cyclenium Pharma is an emerging, privately-held pharmaceutical research and development company that has translated its nearly two decades of pioneering experience, extensive knowledge base and unparalleled expertise in small molecule macrocyclic chemistry into the next generation CMRT drug discovery technology that addresses the shortcomings of earlier efforts in this increasingly important domain. Cyclenium is creating value through progression of internal programs in oncology, infectious diseases and inflammation/pain. In addition, Cyclenium is providing its extensive experience and exploring its CMRT-based QUEST™ screening library in risk-sharing partnerships with leading academic and research driven nonprofit organizations, as well as collaborations with innovative pharmaceutical and biotechnology companies world-wide seeking to modulate unique and difficult disease targets in diverse therapeutic areas. For more information see: www.cyclenium.com.

About Haplogen Bioscience GmbH

Haplogen Bioscience is a privately held biotechnology company in Vienna, Austria, with drug discovery programs to combat viral infectious and other diseases. Haplogen was founded in 2010 as a spin-out of CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences. For more information on Haplogen visit: http://www.haplogen.com.

Contacts:

Helmut Thomas, Ph.D., DABT
President, CEO & CSO
Cyclenium Pharma Inc.
Phone: +1-819-571-4296
hthomas@cyclenium.com

Georg Casari, Ph.D.
Chief Executive Officer
Haplogen Bioscience GmbH
Phone: +43-1-9165522
office@haplogen-bioscience.com

Record changed: 2023-06-05